代谢疾病靶点与生物药研发

代谢疾病 (Metabolic Disorders, MDs) 是一类由于代谢途径中酶或蛋白质功能缺陷引起的复杂疾病，通常由遗传因素、环境因素或两者共同作用引起。这些疾病通常涉及糖代谢、脂代谢、氨基酸代谢、矿物质和骨代谢等异常，进而影响人体正常生理功能。

ACROBiosystems持续专注为生物医药用户提供更加全面的药物开发工具。为满足代谢疾病药物开发需求，ACROBiosystems针对疾病靶点开发了高质量【重组蛋白】、【功能细胞株】、【抗体】、【磁珠】及【抑制剂筛选试剂盒】等产品，适用药物开发不同阶段，全面满足您的生物药开发需求！

糖代谢疾病

1. Haythorne, E., Rohm, M., van de Bunt, M. et al. Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells. Nat Commun 10, 2474 (2019). https://doi.org/10.1038/s41467-019-10189-x
2. Badimon, Lina & Chiva-Blanch, Gemma. (2019). Lipid Metabolism in Dyslipidemia and Familial Hypercholesterolemia. 10.1016/B978-0-12-811297-7.00024-X.
3. Wang Z, Wu X, Chen HN, Wang K. Amino acid metabolic reprogramming in tumor metastatic colonization. Front Oncol. 2023 Mar 14;13:1123192. doi: 10.3389/fonc.2023.1123192. PMID: 36998464; PMCID: PMC10043324.
4. Montaner Ramón A. Risk factors of bone mineral metabolic disorders. Semin Fetal Neonatal Med. 2020 Feb;25(1):101068. doi: 10.1016/j.siny.2019.101068. Epub 2019 Dec 2. PMID: 31862224.